Production and Biological Activity of Secalonic Acid D
AUTOR(ES)
Ciegler, Alex
RESUMO
Twenty isolates of Penicillium oxalicum produced secalonic acid as their major secondary metabolite. Fermentation conditions were determined for toxin production in grain and liquid media. The 50% lethal dose value for mice ranged from 26.5 to 51.7 mg/kg dependent on animal strain and sex, males being more susceptible than females. Secalonic acid was nontoxic and nonteratogenic to the chicken embryo and exhibited poor antibiotic properties. Its potential role in mycotoxicoses is discussed.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=291324Documentos Relacionados
- Secalonic acid D: natural contaminant of corn dust.
- Inhibition by secalonic acid D of oxidative phosphorylation and Ca2+-induced swelling in mitochondria isolated from rat livers.
- Biological Activity of O-β-d-Glucopyranosylzeatin 1
- Biological Activity of Tetrazole Analogues of Indole-3-Acetic Acid and 2,4-Dichlorophenoxyacetic Acid 123
- Bromomonamycins, Unnatural Analogues of the Monamycin Cyclodepsipeptide Antibiotics: Production, Isolation, and Biological Activity