Prospective multicenter study on isolation of human immunodeficiency virus type 1 from homosexual men after seroconversion.
AUTOR(ES)
Gupta, P
RESUMO
A prospective multicenter study was undertaken to isolate human immunodeficiency virus type 1 (HIV-1) from 45 homosexual men for a period of 30 months after seroconversion. Efficiency of HIV-1 isolation from peripheral blood mononuclear cells was relatively stable over time, ranging from 64% at the time of seroconversion to more than 82% after 18 months of seroconversion. However, Kaplan-Meier analysis of HIV-1 culture data indicates that the cumulative proportion of HIV-1 culture positivity at 3, 6, 12, and 18 months after seroconversion was 62, 65, 84, and 92%, respectively. No significant correlation was observed between the presence of HIV-1 p24 antigen in serum, or numbers of CD4+ and CD8+ blood lymphocytes, and HIV-1 isolation within this period of time. These data suggest that HIV-1 viremia in homosexual men gradually increases to almost 100% culture positivity by 18 months after seroconversion.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=270119Documentos Relacionados
- Performance of serological assays for early detection of human immunodeficiency virus type 1 seroconversion.
- Bilateral Bell's palsy and aseptic meningitis in a patient with acute human immunodeficiency virus seroconversion.
- Immunologic function in a cohort of human immunodeficiency virus type 1-seropositive and -negative healthy homosexual men.
- Human Immunodeficiency Virus (HIV)-Positive Sera Obtained Shortly after Seroconversion Neutralize Autologous HIV Type 1 Isolates on Primary Macrophages but Not on Lymphocytes
- Enhanced shedding of cytomegalovirus in semen of human immunodeficiency virus-seropositive homosexual men.
