Protection of cotton rats against experimental Echinococcus multilocularis infections with BCG cell walls.
AUTOR(ES)
Reuben, J M
RESUMO
Previous works has indicated that cotton rats treated with Mycobacterium bovis strain BCG are effectively protected against an infection with the metastatically proliferating metacestodes of Echinococcus multilocularis. In an attempt to induce a similar protection in the absence of tubercular granulomatous lesions, cotton rats were treated with BCG cell walls. A single injection of 150 micrograms of cell walls, emulsified in mineral oil-Tween-saline, 2 weeks before the inoculation of the parasite completely protected the animals against infection with E. multilocularis. This protection was correlated with an increase in the numbers of monocytes and, as judged by acid phosphatase activity, an activation of these cells. This study shows that BCG cell walls are as effective in protecting animals against E. multilocularis as the viable organism.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=414205Documentos Relacionados
- Immunoprophylaxis with BCG of experimental Echinococcus multilocularis infections.
- Immunotherapy of guinea pigs with a transplanted hepatoma: comparison of intralesionally administered killed BCG cells and BCG cell walls.
- In Vitro Activities of Benzimidazoles against Echinococcus multilocularis Metacestodes
- In Vitro Parasiticidal Effect of Nitazoxanide against Echinococcus multilocularis Metacestodes
- Molecular Cloning of a Vaccine Antigen against Infection with the Larval Stage of Echinococcus multilocularis
