Protective effect of vaccination against Mycoplasma pulmonis respiratory disease in rats.
AUTOR(ES)
Cassell, G H
RESUMO
Intravenous vaccination of rats with either viable or Formalin-inactivated Mycoplasma pulmonis reduced the incidence and severity of lower respiratory tract lesions after intranasal challenge with viable organisms. Intranasal vaccination with killed organisms reduced the severity of rhinitis, but did not affect lesions in any other region of the respiratory tract. The maximum protection against upper tract lesions (rhinitis, otitis, and laryngotracheitis) was provided by intravenous immunization with viable organisms. Dual vaccination (intraperitoneal plus intranasal) with killed organisms provided no significant protection in any segment of the tract. However, these ineffective vaccine regimens did not potentiate the lesions. These results conclusively demonstrate that vaccination of rats against mycoplasma respiratory disease is feasible and also suggest that systemic vaccination may provide greater protection for the lungs than intranasal vaccination, at least when equivalent antigen doses are used.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=421959Documentos Relacionados
- Protective Effect of Vaccines on Mycoplasma pulmonis-Induced Respiratory Disease of Mice
- Intracage ammonia promotes growth of Mycoplasma pulmonis in the respiratory tract of rats.
- Comparison of techniques for primary isolation of respiratory Mycoplasma pulmonis from rats.
- Protective effect of piperacillin against the nephrotoxicity of cisplatin in rats.
- In utero transmission of Mycoplasma pulmonis in experimentally infected Sprague-Dawley rats.