Protective roles of pulmonary rehabilitation mixture in experimental pulmonary fibrosis in vitro and in vivo
AUTOR(ES)
Zhang, L., Ji, Y.X., Jiang, W.L., Lv, C.J.
FONTE
Braz J Med Biol Res
DATA DE PUBLICAÇÃO
08/05/2015
RESUMO
Abnormal high mobility group protein B1 (HMGB1) activation is involved in the pathogenesis of pulmonary fibrosis. Pulmonary rehabilitation mixture (PRM), which combines extracts from eight traditional Chinese medicines, has very good lung protection in clinical use. However, it is not known if PRM has anti-fibrotic activity. In this study, we investigated the effects of PRM on transforming growth factor-β1 (TGF-β1)-mediated and bleomycin (BLM)-induced pulmonary fibrosis
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