Protein X of Streptococcus agalactiae induces opsonic antibodies in cows.
AUTOR(ES)
Rainard, P
RESUMO
Protein X of Streptococcus agalactiae is a surface protein frequently associated with strains isolated from cases of mastitis of dairy cows. By immunizing cows with purified protein X, we obtained an antibody response which was restricted to X-bearing strains of S. agalactiae in a whole-cell enzyme-linked immunosorbent assay. This response resulted in an increase in the opsonic activity of serum for strains bearing protein X, as assessed through the augmentation of the chemiluminescence response of phagocytosing polymorphonuclear cells and through an increased ingestion of bacteria, although the proportion of ingested bacteria which were killed (about 60%) remained unchanged. Protein X behaved as a target of opsonins and, as such, could be a protective antigen worth incorporating in a vaccine against S. agalactiae mastitis.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=270221Documentos Relacionados
- Isotype antibody response in cows to Streptococcus agalactiae group B polysaccharide-ovalbumin conjugate.
- Phenotypic and Molecular Characteristics of Streptococcus agalactiae Isolates Recovered from Milk of Dairy Cows in Brazil
- Surface protein of a Streptococcus agalactiae isolate.
- Mitochondrial DNA polymorphism in a maternal lineage of Holstein cows.
- Prevalence of rotavirus and coronavirus antigens in the feces of normal cows.
