Proviruses are adjacent to c-myc in some murine leukemia virus-induced lymphomas.
AUTOR(ES)
Steffen, D
RESUMO
Sixty-one murine leukemia virus-induced lymphomas were examined for evidence of proviral insertions adjacent to known oncogenes. Five of these lymphomas were found to have alterations adjacent to c-myc. Two of the lymphomas with altered c-myc sequences were examined in detail. Evidence was obtained showing that the alterations in the c-myc sequences in these two lymphomas were the result of proviral integrations. This result suggests that lymphomagenesis by murine leukemia viruses can result from insertional mutagenesis of cellular oncogenes.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=345444Documentos Relacionados
- Molecular analysis of the c-myc locus in normal tissue and in avian leukosis virus-induced lymphomas.
- Absence of missense mutations in activated c-myc genes in avian leukosis virus-induced B-cell lymphomas.
- Deregulation of the c-myc oncogene in virus-induced thymic lymphomas of AKR/J mice.
- Characterization of pal-1, a common proviral insertion site in murine leukemia virus-induced lymphomas of c-myc and Pim-1 transgenic mice.
- Long terminal repeat enhancer core sequences in proviruses adjacent to c-myc in T-cell lymphomas induced by a murine retrovirus.