Pseudomonas aeruginosa Exoenzyme S Is a Biglutamic Acid ADP-Ribosyltransferase
AUTOR(ES)
Radke, Jay
FONTE
American Society for Microbiology
RESUMO
Kinetic analysis of two mutations within Pseudomonas aeruginosa exoenzyme S (ExoS) showed that a E379D mutation inhibited expression of ADP-ribosyltransferase activity but had little effect on the expression of NAD glycohydrolase activity while a E381D mutation inhibited expression of both activities. These data identify ExoS as a biglutamic acid ADP-ribosyltransferase, where E381 is the catalytic residue and E379 contributes to the transfer of ADP-ribose to the target protein.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=96488Documentos Relacionados
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