Pseudomonas aeruginosa mutants altered in their sensitivity to the effect of iron on toxin A or elastase yields.
AUTOR(ES)
Sokol, P A
RESUMO
Iron affects yields of toxin A, alkaline protease, elastase, pyochelin, and pyoverdin in Pseudomonas aeruginosa. Mutants of P. aeruginosa PAO1 resistant to the effect of iron on toxin (toxC) or elastase (elaC) yields were isolated. Two types of mutants were isolated: iron transport and iron regulatory mutants. The toxC regulatory mutants produced toxin A in medium containing iron; however, yields of elastase and alkaline protease remained sensitive to regulation by iron. The elaC regulatory mutants were resistant to the effect of iron on elastase yields, but toxin A and alkaline protease yields were decreased by iron, analogous to the parent strain. These data suggest that toxin A, elastase, and alkaline protease yields can be independently regulated by iron.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=220326Documentos Relacionados
- Effect of iron on yields of exotoxin A in cultures of Pseudomonas aeruginosa PA-103.
- Influence of Iron on Yields of Extracellular Products in Pseudomonas aeruginosa Cultures
- Differences in Sensitivity to PA-1806 among Iron Transport Mutants of Pseudomonas aeruginosa Compared to Escherichia coli
- Effect of medium composition on the apparent sensitivity of Pseudomonas aeruginosa to gentamicin
- Contribution of toxin A and elastase to virulence of Pseudomonas aeruginosa in chronic lung infections of rats.
