Pseudorabies virus-induced suppression of major histocompatibility complex class I antigen expression.
AUTOR(ES)
Mellencamp, M W
RESUMO
The ability of pseudorabies virus (PrV) to down-modulate expression of major histocompatibility complex class I antigens in murine and porcine cells was investigated. When quantified by flow cytometry, surface expression of class I Kk and Dk antigens on PrV-infected cells decreased by 60% or more. Down-modulation was associated with a decrease in total cellular class I antigens, indicating regulation at the transcriptional or posttranscriptional level. PrV did not suppress expression of transferrin receptor, suggesting a selective regulatory mechanism.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=240998Documentos Relacionados
- Inhibition of Major Histocompatibility Complex Class II-Dependent Antigen Presentation by Neutralization of Gamma Interferon Leads to Breakdown of Resistance against Measles Virus-Induced Encephalitis
- Infection by polyomavirus of murine cells deficient in class I major histocompatibility complex expression.
- Recovery from Friend disease in mice with reduced major histocompatibility complex class I expression.
- Down-regulation of major histocompatibility complex class I synthesis by murine cytomegalovirus early gene expression.
- Endogenous expression of E1A in human cells enhances the effect of adenovirus E3 on class I major histocompatibility complex antigen expression.