Purification and identification of pituitary cytotropic factor.
AUTOR(ES)
Porter, J C
RESUMO
It has been shown that the pituitary contains a cytotropic factor (CTF) that stimulates the secretion of catecholamines by dopaminergic neurons of the hypothalamus. In the present study, CTF was purified from rat pituitaries and found by means of mass spectrometric analysis to be adenosine. This finding was corroborated by the observations that CTF behaves identically to adenosine when subjected to liquid chromatography, is inactivated and converted to inosine by adenosine deaminase, and is qualitatively and quantitatively indistinguishable from adenosine in its biological activity. It is concluded that pituitary adenosine is a trophic factor for hypothalamic dopaminergic neurons.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=41692Documentos Relacionados
- Identification, purification, and biochemical characterization of U2 small nuclear ribonucleoprotein auxiliary factor.
- Identification, purification, and characterization of a mast cell-associated cytolytic factor related to tumor necrosis factor.
- Isolation and partial molecular characterization of pituitary fibroblast growth factor.
- Pituitary follicular cells secrete an inhibitor of aortic endothelial cell growth: identification as leukemia inhibitory factor.
- Purification of the late transcription system of vaccinia virus: identification of a novel transcription factor.