PVR plays a critical role via JNK activation in thorax closure during Drosophila metamorphosis
AUTOR(ES)
Ishimaru, Satoshi
FONTE
Nature Publishing Group
RESUMO
PVR, the Drosophila homolog of the PDGF/VEGF receptor, has been implicated in border cell migration during oogenesis and hemocyte migration during embryogenesis. It was earlier shown that Mbc, a CDM family protein, and its effector, Rac, transduced the guidance signal from PVR during border cell migration. Here we demonstrate that PVR is also required for the morphogenetic process, thorax closure, during metamorphosis. The results of genetic and biochemical experiments indicate that PVR activates the JNK pathway. We present evidence showing Crk (an adaptor molecule), Mbc, ELMO (a homolog of Caenorhabditis elegans CED-12 and mammalian ELMO), and Rac to be mediators of JNK activation by PVR. In addition, we suppose that not only Rac but also Cdc42 is activated and involved in JNK activation downstream of PVR.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=524349Documentos Relacionados
- JNK and decapentaplegic signaling control adhesiveness and cytoskeleton dynamics during thorax closure in Drosophila
- Activation of the JNK pathway during dorsal closure in Drosophila requires the mixed lineage kinase, slipper
- CD155/PVR plays a key role in cell motility during tumor cell invasion and migration
- puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila
- p21-Activated Kinase 1 Plays a Critical Role in Cellular Activation by Nef