Quantitative Analysis of the Antiviral Activity of CD8+ T Cells from Human Immunodeficiency Virus-Positive Asymptomatic Patients with Different Rates of CD4+ T-Cell Decrease

AUTOR(ES)

Salerno-Gonçalves, Rosângela

FONTE

American Society for Microbiology

RESUMO

We have measured in 22 asymptomatic human immunodeficiency virus type 1-infected patients (10 rapid progressors and 12 slow progressors) the proviral load of CD4+ T cells homogeneously superinfected by the same dose of a non-syncytium-inducing virus in the presence or in the absence of autologous CD8+ T cells. We demonstrated that the antiviral activity of CD8+ T cells was highly predictive of the rate of peripheral CD4+ T-cell decline.

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