Quinolone Resistance Mutations in the GrlB Protein of Staphylococcus aureus
AUTOR(ES)
Tanaka, Mayumi
FONTE
American Society for Microbiology
RESUMO
Two altered GrlB proteins (one with an Asp-432→Asn alteration and one with an Asn-470→Asp alteration) of Staphylococcus aureus were purified as fusion proteins to maltose-binding protein. The 50% inhibitory concentrations of levofloxacin were 14 and 3.4 μg/ml against topoisomerase IV containing GrlB proteins with alterations at positions 432 and 470, respectively. These results suggest that the alteration of Asp to Asn at position 432 may be responsible for quinolone resistance.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=105993Documentos Relacionados
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