Random Genetic Drift Determines the Level of Mutant mtDNA in Human Primary Oocytes

AUTOR(ES)

Brown, D. T.

FONTE

The American Society of Human Genetics

RESUMO

We measured the proportion of mutant mtDNA (mutation load) in 82 primary oocytes from a woman who harbored the A3243G mtDNA mutation. The frequency distribution of mutation load indicates that random drift is the principal mechanism that determines the level of mutant mtDNA within individual oocytes.

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