Random walk analysis of potassium fluxes associated with nerve impulses.
AUTOR(ES)
Clay, J R
RESUMO
We present a novel recursion method for obtaining theoretical expressions for unidirectional single-file fluxes of ions through narrow membrane channels containing an arbitrary number of ion sites. The theory is applied to experimental tracer fluxes associated with nerve impulses from cephalopod giant axon membranes at various temperatures between 7 degrees and 27 degrees. The comparison between the theoretical and experimental one-way fluxes suggests that the potassium channel in nerve membrane contains three ion sites, which is consistent with the deduction by Hodgkin and Keynes that the potassium channel contains two or three sites on the basis of the ratio of tracer influx to tracer efflux. The analytical results in this paper provide a further test of the single-file model for nerve and other membrane preparations.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=431800Documentos Relacionados
- Potassium Fluxes in Chlamydomonas reinhardtii (II. Compartmental Analysis).
- Shape anisotropy of a single random-walk polymer
- Molecular motors: thermodynamics and the random walk.
- Three dimensional analysis of Schwann cells associated with unmyelinated nerve fibres in human sural nerve.
- Asymptotic form for random walk survival probabilities on three-dimensional lattices with traps