Rapid segregation of heteroplasmic bovine mitochondria.

AUTOR(ES)

Ashley, M V

RESUMO

By following the transmission of a heteroplasmic mitochondrial DNA mutation through four generations of Holstein cows, we have documented that substantial shifts in the levels of heteroplasmy can occur between single mammalian generations, that neutral mitochondrial genotypes can segregate in different directions in offspring of the same female, and that a return to homoplasmy may occur in only two or three generations. This apparently rapid rate of mitochondrial DNA segregation in mammals contrasts to the much slower rates observed previously in insects and suggest fundamental differences between taxa regarding the mechanisms of mitochondrial gene transmission.

Documentos Relacionados

• Dehydrogenase and transhydrogenase properties of the soluble NADH dehydrogenase of bovine heart mitochondria.
• A rapid method for measuring the steady state levels of mitochondrial RNA in whole mitochondria.
• Targeting proteins into mitochondria.
• Pronounced segregation of donor mitochondria introduced by bovine Ooplasmic tranfer to the female germ-line.
• Biosynthesis of Cardiolipin in Plant Mitochondria.