RATES OF POLYPEPTIDE CHAIN ASSEMBLY IN LIVER IN VIVO: RELATION TO THE MECHANISM OF TEMPERATURE ACCLIMATION IN OPSANUS TAU*
AUTOR(ES)
Haschemeyer, Audrey E. V.
RESUMO
A simple translational model, present herein, permits experimental determination of the rates of protein synthesis in vivo in terms of a time constant representing the average assembly time of the polypeptide chains. The model has been used to interpret incorporation of radioactive amino acids into toadfish liver fractions as a function of time after hepatic portal vein injection. The results suggest that the increase in liver protein synthesis produced by cold acclimation is due to a more rapid rate of addition of amino acid residues to the growing polypeptide chains. The finding is consistent with the greater aminoacyl transferase activity in livers of cold-acclimated fish.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=285964Documentos Relacionados
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