Rectal biopsy as a prognostic guide in Crohn's colitis.
AUTOR(ES)
Ward, M
RESUMO
In a retrospective study, 64 rectal biopsies from 27 patients with Crohn's disease limited to the large bowel have been reviewed using a semiquantitative grading of histological abnormality. The subsequent clinical course was assessed independently, and patients were included in one of four categories: (1) remaining asymptomatic; (2) showing continued moderate inflammatory activity; (3) requiring colectomy; and (4) dying as a direct result of colonic disease. Biopsies from group (4) showed a greater degree of histological abnormality than those in the other three groups. This difference was statistically significant for first biopsies ((4)-(1) p less than 0-05; (4)-(2) p less than 0-05). In any one patient the histological appearances were relatively constant from one biopsy to the next. The presence of either fissuring or ulceration suggested a poor prognosis.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=476334Documentos Relacionados
- Cytomegalovirus infection in Crohn's colitis
- Frequency of epithelioid granulomas in colonoscopic biopsy specimens from paediatric and adult patients with Crohn's colitis
- Diagnostic difficulty arising from rectal recovery in ulcerative colitis.
- Biochemical analysis of enzymic markers of inflammation in rectal biopsies from patients with ulcerative colitis and Crohn's disease.
- Occult dysplasia in a localized giant pseudopolyp in Crohn’s colitis: A case report