Regulation of Bacterial Cell Walls: Turnover of Cell Wall in Staphylococcus aureus

AUTOR(ES)

Wong, W.

RESUMO

The cell wall of Staphylococcus aureus was shown to undergo turnover during exponential growth. The rate of turnover, about 15% per generation, was identical for both cell wall polymers, peptidoglycan and teichoic acid. Both the old and newly synthesized wall material appeared to undergo turnover at similar rates. The rate of turnover followed first-order kinetics until more than 90% of the original wall was lost. Cell wall turnover was completely blocked under conditions of unbalanced synthesis known to inhibit cellular autolysis, e.g., addition of chloramphenicol. Cell wall turnover was shown to occur in a number of different strains of S. aureus and appears to be widely distributed in this species.

Documentos Relacionados

• Regulation of bacterial cell walls: correlation between autolytic activity and cell wall turnover in Staphylococcus aureus.
• Regulation of the Bacterial Cell Wall: Isolation and Characterization of Peptidoglycan Mutants of Staphylococcus aureus1
• Inhibition of cell wall turnover and autolysis by vancomycin in a highly vancomycin-resistant mutant of Staphylococcus aureus.
• Cell wall sorting of lipoproteins in Staphylococcus aureus.
• Autolysis in Staphylococcus aureus: Preferential Release of Old Cell Walls