Relationship between Candida albicans Virulence during Experimental Hematogenously Disseminated Infection and Endothelial Cell Damage In Vitro

AUTOR(ES)

Sanchez, Angela A.

FONTE

American Society for Microbiology

RESUMO

Candida albicans must penetrate the endothelial cell lining of the vasculature to invade the deep tissues during a hematogenously disseminated infection. We compared 27 C. albicans mutants with their wild-type parent for their capacity to damage endothelial cells in vitro and cause a lethal infection in mice following tail vein inoculation. Of 10 mutants with significantly impaired capacity to damage endothelial cells, all had attenuated virulence. Therefore, the endothelial cell damage assay can be used as a screen to identify some virulence factors relevant to hematogenously disseminated candidiasis.

Documentos Relacionados

• Relationship between cell surface composition, adherence, and virulence of Candida albicans.
• Need for Early Antifungal Treatment Confirmed in Experimental Disseminated Candida albicans Infection
• Avirulence of Candida albicans CaHK1 Mutants in a Murine Model of Hematogenously Disseminated Candidiasis
• Penetration and damage of endothelial cells by Candida albicans.
• Gamma interferon protects endothelial cells from damage by Candida albicans by inhibiting endothelial cell phagocytosis.