Relationship between superoxide dismutase and melanin in a pathogenic fungus.

AUTOR(ES)

Jacobson, E S

RESUMO

Since melanin is considered a virulence factor in Cryptococcus neoformans, its suppression at 37 degrees C has been perplexing. We now show an opposite thermal regulation of superoxide dismutase (SOD), consistent with a compensatory mechanism. Moreover, we demonstrate normal SOD and catalase levels in albino, oxygen-sensitive mutants. These results suggest that melanin is an antioxidant factor comparable in importance to SOD.

Documentos Relacionados

• Relationship between superoxide dismutase and pathogenic mechanisms of Listeria monocytogenes.
• Immunosuppression in vitro by a metabolite of a human pathogenic fungus.
• An inherited "neoplasm" in fungus.
• Genetic, enzymatic, and pathogenic studies of the iron superoxide dismutase of Campylobacter jejuni.
• Ocular fungus. Report of two cases.