Release of (oligo) peptidyl-tRNA from ribosomes by erythromycin A.
AUTOR(ES)
Otaka, T
RESUMO
Erythromycin A released peptidyl-tRNA in the in vitro polypeptide synthesis system with bacterial components programmed by synthetic polynucleotide. This is consistent with our hypothesis that erythromycin A inhibits translocation by preventing proper situation of oligopeptidyl-tRNA in the donor (D) site on ribosomes.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=432827Documentos Relacionados
- Erythromycin, carbomycin, and spiramycin inhibit protein synthesis by stimulating the dissociation of peptidyl-tRNA from ribosomes.
- Lincosamide antibiotics stimulate dissociation of peptidyl-tRNA from ribosomes.
- Peptidyl-tRNA hydrolase from Sulfolobus solfataricus
- Dissociation rates of peptidyl-tRNA from the P-site of E.coli ribosomes.
- Identification of 50S Proteins at the Peptidyl-tRNA Binding Site of Escherichia coli Ribosomes
