Renin in renal cell carcinoma--an immunocytochemical study using an antibody to pure human renin.
AUTOR(ES)
Lindop, G B
RESUMO
We have studied a series of 19 primary renal cell carcinomas using an antibody to pure human renin and the indirect PAP technique. Seven tumours contained immunoreactive renin. No renin was identified in seven cases of metastatic tumour within the kidney, but immunoreactive renin was present in two out of seven metastatic renal cell carcinomas in other organs. None of the subjects had clinical, biochemical or histological evidence of excess renin secretion. We suggest that renal cell carcinoma may commonly secrete renin and that the hormone may be biologically inactive.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=498613Documentos Relacionados
- An ultrastructural and immunocytochemical study of a renal carcinoma secreting inactive renin.
- Myxoid renal cell carcinoma: histological, immunocytochemical and ultrastructural study.
- Characterization of inactive renin from human kidney and plasma. Evidence of a renal source of circulating inactive renin.
- Human decidua is a major source of renin.
- Immunocytochemical identification of breast carcinoma cells in effusions using a monoclonal antibody.