Replication of latent Epstein-Barr virus genomes in Raji cells.
AUTOR(ES)
Adams, A
RESUMO
The replication of the 50 to 60 latent, predominantly extrachromosomal, Epstein-Barr virus genomes maintained by the Burkitt-lymphoma-derived Raji cell line was investigated by using a Meselson-Stahl density transfer approach. Samples of DNA isolated from cells cultivated for different periods in bromodeoxyuridine-supplemented medium were fractionated according to density, and the distribution of viral and cellular DNAs among the heavy-, hybrid-, and light-density species was quantitated. The results indicate that the majority of latent Epstein-Barr virus DNA plasmids each replicate once during the cell cycle.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=254169Documentos Relacionados
- Electron microscopic evidence for replication of circular Epstein-Barr virus genomes in latently infected Raji cells.
- Epstein-Barr virus-specific DNA polymerase in virus-nonproducer Raji cells.
- Transforming activity of Epstein-Barr virus obtained by superinfection of Raji cells.
- Epstein-Barr virus gene expression in P3HR1-superinfected Raji cells.
- Replication of Epstein-Barr virus: ultrastructural and immunofluorescent studies of P3HR1-superinfected Raji cells.
