Replicational and transcriptional selection on codon usage in Borrelia burgdorferi
AUTOR(ES)
McInerney, James O.
FONTE
The National Academy of Sciences
RESUMO
With more than 10 fully sequenced, publicly available prokaryotic genomes, it is now becoming possible to gain useful insights into genome evolution. Before the genome era, many evolutionary processes were evaluated from limited data sets and evolutionary models were constructed on the basis of small amounts of evidence. In this paper, I show that genes on the Borrelia burgdorferi genome have two separate, distinct, and significantly different codon usages, depending on whether the gene is transcribed on the leading or lagging strand of replication. Asymmetrical replication is the major source of codon usage variation. Replicational selection is responsible for the higher number of genes on the leading strands, and transcriptional selection appears to be responsible for the enrichment of highly expressed genes on these strands. Replicational–transcriptional selection, therefore, has an influence on the codon usage of a gene. This is a new paradigm of codon selection in prokaryotes.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=27958Documentos Relacionados
- Synonymous Codon Usage in Drosophila Melanogaster: Natural Selection and Translational Accuracy
- Does recombination improve selection on codon usage? Lessons from nematode and fly complete genomes
- Codon usage in Caenorhabditis elegans: delineation of translational selection and mutational biases.
- Synonymous codon usage is subject to selection in thermophilic bacteria
- Synonymous codon usage in Bacillus subtilis reflects both translational selection and mutational biases.