Resting Skeletal Muscle Membrane Potential as an Index of Uremic Toxicity: A PROPOSED NEW METHOD TO ASSESS ADEQUACY OF HEMODIALYSIS
AUTOR(ES)
Cotton, James R.
RESUMO
Electrochemical disturbances of skeletal muscle cells in untreated uremia are characterized by an increase in the intracellular sodium and chloride content, a decrease in intracellular potassium, and a low resting membrane potential. In this study, we have reexamined the foregoing and, in addition, have examined the effects of hemodialysis. Three groups of patients were studied. In the first group of 22 uncomplicated uremic patients, whose creatinine clearance (Ccr) ranged from 2 to 12 cm3/min per 1.73 m2, resting transmembrane potential difference (Em) of skeletal muscle cells was measured. In each of the nine patients whose Ccr ranged between 6.3 and 12 cm3/min, the Em was normal (i.e., −90.8±0.9 mV, mean±SEM). However, as Ccr dropped below 6.3 cm/min, the Em became progressively reduced and assumed a linear relationship with the Ccr.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=371979Documentos Relacionados
- Skeletal Muscle Resting Membrane Potential in Potassium Deficiency
- Heat-induced superaggregation of amphotericin B reduces its in vitro toxicity: a new way to improve its therapeutic index.
- Responses of Plants to Pesticide Toxicity: an Overview
- Resting transmembrane potential difference of skeletal muscle in normal subjects and severely ill patients
- Muscle fibre excitability and resting membrane potential in hamster muscular dystrophy.