Restoration of Mga Function to a Streptococcus pyogenes Strain (M Type 50) That Is Virulent in Mice
AUTOR(ES)
Limbago, Brandi
FONTE
American Society for Microbiology
RESUMO
The Mga protein in B514Sm, a Streptococcus pyogenes strain isolated as a mouse pathogen, contains amino acid substitutions at conserved sites that render the protein defective. Replacement of mga50 with the functional homolog mga4.1 restored full expression of Mga-regulated proteins. Restoration of Mga function did not affect fibrinogen binding, nor did it affect virulence in several mouse models of group A streptococcus infection.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=98010Documentos Relacionados
- Attenuated Expression of the mga Virulence Regulon in an M Serotype 50 Mouse-Virulent Group A Streptococcal Strain
- DNA sequencing and gene expression of the emm gene cluster in an M50 group A streptococcus strain virulent for mice.
- Physical and genetic chromosomal map of an M type 1 strain of Streptococcus pyogenes.
- Fibronectin binding to a Streptococcus pyogenes strain.
- Transcriptional Activation of sclA by Mga Requires a Distal Binding Site in Streptococcus pyogenes