Restrição calorica e suplementação com vitamina E no rato submetido ao exercicio fisico exaustivo

AUTOR(ES)

Suzana Lima de Oliveira

DATA DE PUBLICAÇÃO

1999

RESUMO

The present study was designed to investigate the effects of caloric (carbohydrate) restriction (CR) and vitamin E supplementation on stress oxidative and others exercise-induced metabolic modifications. Male Wistar, eleven-wk old rats were fed control (C)(AIN-93M), or restricted amounts of a modified control (R), or control plus vitamin E (1425 UI of all-rac--tocopheryl acetate)(S) diets. After feeding the diets for five months, the animais in each group were divided into exercised (E) and non-exercised (NE) categories. Before being killed, the rats of the exercised category were required to run on a treadmill to exhaustion. The time to reach exhaustion was registered and lipid peroxidation (thiobarbituric acid¬reactive substances [TBARS]), protein damage (reactive protein carbonyls), GSH (glutathion) and vitamin E in gastrocnemius, liver or plasma, and hepatic and muscular glycogen, plasma glucose, insulin and lactate were determined. Caloric restriction increased resistance to exhaustion, whereas vitamin E supplementation presented tendency to décrease it. Lipid peroxidation was significantly lower in livers and muscles of rats fed S diet when compared to the others groups. Exercise slightly decreased TBARS in muscle, whereas GSH in liver and reactive protein carbonyls in liver and muscle were similar for ali groups. Vitamin E supplementation increased vitamin E levels in liver, muscle and plasma, but exercise decreased it in plasma. Caloric restriction increased hepatic glycogen, but did not produce any effect in the insulin and lactate concentrations. When associated to exercise, CR lowered the glycemic levels. Caloric (carbohYdrate) restriction increased resistance to exhaustive without depleting vitamin E stotes or exacerbating oxidative damage. Although vitamin E supplementation showed a protective effect against lipid peroxidation, which was not afforded by caloric restriction, there was a decreased physical endurance, when compared to caloric restriction, but not to the normal diet. The biochemical basis for the choking effect shown by vitamin E supplementation is not known.

ASSUNTO(S)

alimentos vitamina e

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