Restricting Expression Prolongs Expression of Foreign Genes Introduced into Animals by Retroviruses
AUTOR(ES)
Pinto, Valerian B.
FONTE
American Society for Microbiology
RESUMO
If foreign genes are ubiquitously expressed in mice using a viral vector, expression is abrogated by CD8+ cells in 2 to 4 weeks. However, if the expression of the genes is confined to skeletal muscle cells, the CD8+ T-cell response is much weaker and expression is maintained for more than 6 weeks. These data show that restricting the expression of foreign genes to skeletal muscle cells and presumably to other cells that are inefficient at antigen presentation can prolong the expression of a foreign gene product.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=102059Documentos Relacionados
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