Reversal of natural killing susceptibility in target cells expressing transfected class I HLA genes.

AUTOR(ES)

Storkus, W J

RESUMO

A number of studies have suggested that resistance of target cells to natural killing (NK) may be correlated with their level of expression of major histocompatibility complex (MHC) class I antigens. To examine this hypothesis directly, a NK-sensitive class I-deficient human B-cell line was transfected with MHC class I genes. The expression of transfected HLA, but not H-2, class I gene products resulted in loss of susceptibility to human NK-mediated conjugation and cytolysis. Furthermore, this protection did not extend to cytotoxicity mediated by interleukin 2-stimulated human NK effector cells.

Documentos Relacionados

• Class I-induced resistance to natural killing: identification of nonpermissive residues in HLA-A2.
• Complete nucleotide sequence of a functional class I HLA gene, HLA-A3: implications for the evolution of HLA genes.
• CpG islands and HTF islands in the HLA class I region: investigation of the methylation status of class I genes leads to precise physical mapping of the HLA-B and -C genes.
• Expression in L cells of transfected class I genes from the mouse major histocompatibility complex.
• Gold induced nephropathy in rheumatoid arthritis and HLA class II genes.