Riboflavin is a component of the Na+-pumping NADH–quinone oxidoreductase from Vibrio cholerae

AUTOR(ES)

Barquera, Blanca

FONTE

National Academy of Sciences

RESUMO

Flavins are cofactors in many electron-transfer enzymes. Typically, two types of flavins perform this role: 5′-phosphoriboflavin (FMN) and flavin-adenine dinucleotide (FAD). Both of these are riboflavin derivatives, but riboflavin itself has never been reported to be an enzyme-bound component. We now report that tightly bound riboflavin is a component of the NADH-driven sodium pump from Vibrio cholerae.

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