Ribosomal Resistance to Streptomycin and Spectinomycin in Neisseria gonorrhoeae
AUTOR(ES)
Maness, Michael J.
RESUMO
A cell-free protein synthesizing system was used to study the mechanism of resistance to streptomycin (Str) and spectinomycin (Spc) in laboratory mutants and clinical isolates of Neisseria gonorrhoeae. The 70S ribosomes from sensitive strains were sensitive to the effects of Str and Spc on synthesis directed by several synthetic polynucleotide messengers, whereas 70S ribosomes from resistant strains were resistant to these same effects. In each case, the alteration was localized to the 30S ribosomal subunit by studying antibiotic sensitivities of hybrid 70S ribosomes formed by combining subunits from sensitive and resistant strains. No evidence was found for streptomycin- or spectinomycin-inactivating enzymes.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=245914Documentos Relacionados
- Genetic Transformation of Neisseria gonorrhoeae to Streptomycin Resistance
- Intrageneric transformation of neisseria gonorrhoeae and neisseria perflava to streptomycin resistance and nutritional independence.
- Sensitivity of Neisseria gonorrhoeae to spectinomycin and thiamphenicol.
- Testing sensitivity of Neisseria gonorrhoeae to spectinomycin.
- Streptomycin and Spectinomycin Resistance Mediated by Plasmids