RNA synthesis in isolated brian nuclei after administration of d-lysergic acid diethylamide (LSD) in vivo.
AUTOR(ES)
Brown, I R
RESUMO
RNA synthesis in isolated brain nuclei was analyzed 2.5 hr after the intravenous administration of d-lysergic acid diethylamide (LSD) to young rabbits. The drug stimulated transcription by 54% in brain stem nuclei and by 13% in cerebral hemisphere nuclei expressed over saline controls. Both nucleoplasmic and nucleolar RNA synthesis were increased. The main activity in the isolated nuclei assay was due to nucleoplasmic RNA polymerase, since alpha-amanitin reduced synthesis by over 70% in either drug or control treatments.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=432415Documentos Relacionados
- Antagonism of histamine-activated adenylate cyclase in brain by D-lysergic acid diethylamide.
- The effects of D-lysergic acid diethylamide tartrate (LSD-25) on the cholinesterases and monoamine oxidase in the spinal cord: a possible factor in the mechanism of hallucination
- Heat shock protein in mammalian brain and other organs after a physiologically relevant increase in body temperature induced by D-lysergic acid diethylamide.
- Dietilamida do ácido lisérgico (LSD) e N,N-dimetiltriptamina (DMT) como substratos de peroxidases: uma possível rota de metabolização
- Selective labeling of serotonin receptors by d-[3H]lysergic acid diethylamide in calf caudate.