Role for the class A macrophage scavenger receptor in the phagocytosis of apoptotic thymocytes in vitro.

AUTOR(ES)

Platt, N

RESUMO

Numerous immature thymocytes undergo apoptosis and are rapidly engulfed by phagocytic thymic macrophages. The macrophage surface receptors involved in apoptotic thymocyte recognition are unknown. We have examined the role of the class A macrophage scavenger receptor (SR-A) in the engulfment of apoptotic thymocytes. Uptake of steroid-treated apoptotic thymocytes by thymic and inflammatory-elicited SR-A positive macrophages is partially inhibited by an anti-SR-A mAb and more completely by a range of scavenger receptor ligands. Thymic macrophages from mice with targeted disruption of the SR-A gene show a 50% reduction in phagocytosis of apoptotic thymocytes in vitro. These data suggest that SR-A may play a role in the clearance of dying cells in the thymus.

Documentos Relacionados

• Macrophage Class A Scavenger Receptor-Mediated Phagocytosis of Escherichia coli: Role of Cell Heterogeneity, Microbial Strain, and Culture Conditions In Vitro
• Is the class A macrophage scavenger receptor (SR-A) multifunctional? — The mouse’s tale
• Inhibition of macrophage phagocytosis by Bacteroides fragilis in vivo and in vitro.
• Scavenger receptor pathway for lipopolysaccharide binding to Kupffer and endothelial liver cells in vitro.
• The Class A Macrophage Scavenger Receptor Is a Major Pattern Recognition Receptor for Neisseria meningitidis Which Is Independent of Lipopolysaccharide and Not Required for Secretory Responses