Role of complement in chemotaxis: study of a localized infection.
AUTOR(ES)
Wilson, D M
RESUMO
A model of Escherichia coli-induced pyelonephritis was used to study the effect of complement depletion in an organ-specific, nonimmunological inflammatory lesion in rats. In this model of a local infection, which can be considered to be nonspecific inflammatory stimulus, the depletion of complement by the administration of a purified cobra venom factor did not alter the course of the disease. There were minor differences when the results from complement-depleted and normocomplementemic animals were compared, but the composition of the inflammatory infiltrate was not greatly altered. Therefore, the presence of C3 and a functional complement system are relatively unimportant factors in determining the characteristics of the inflammatory response in a localized infection-induced lesion.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=551066Documentos Relacionados
- Role of methionine in bacterial chemotaxis: requirement for tumbling and involvement in information processing.
- Role of the CheW protein in bacterial chemotaxis: overexpression is equivalent to absence.
- Quantitative modeling of sensitivity in bacterial chemotaxis: The role of coupling among different chemoreceptor species
- Design and Diversity in Bacterial Chemotaxis: A Comparative Study in Escherichia coli and Bacillus subtilis
- Sensory adaptation in bacterial chemotaxis: regulation of demethylation.