Role of IL-12 in Staphylococcus aureus-triggered arthritis and sepsis

AUTOR(ES)

Hultgren, Olof H

FONTE

BioMed Central

RESUMO

The present study demonstrates that endogenous production of IL-12 is crucial for survival in Staphylococcus aureus-induced arthritis in mice. Staphylococcal load is enhanced in several organs, because of lack of IL-12. This might be due to decreased production of IFN-γ in IL-12-deficient mice. Although IL-12-deficient mice were exposed to higher staphylococcal load, they demonstrated no increased severity of arthritis as compared with control animals.

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