Scrapie Pathogenesis in Subclinically Infected B-Cell-Deficient Mice

AUTOR(ES)

Frigg, Rico

FONTE

American Society for Microbiology

RESUMO

Prion infections can present without clinical manifestations. B-cell deficiency may be a model for subclinical transmissible spongiform encephalopathy, since it protects mice from disease upon intraperitoneal administration of scrapie prions; however, a proportion of B-cell-deficient mice accumulate protease-resistant prion protein in their brains. Here, we have characterized this subclinical disease. In addition, we have studied the possibility that a neurotoxic factor secreted by B cells may contribute to pathogenesis.

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