Screening of blood donors for IgA deficiency: a study of the donor population of south-west England.

AUTOR(ES)

Holt, P D

RESUMO

Altogether 29 745 English blood donors were screened for IgA deficiency by double diffusion analysis; 57 had apparent absence of IgA, a frequency of 1:522. Further examination by the more sensitive haemagglutination inhibition assay revealed 34 samples having no detectable IgA, a frequency of 1:875. All donors negative by double diffusion analysis were tested for the presence of antibodies to IgA. Six class specific anti IgA antibodies and four anti IgA antibodies of limited specificity were detected. Three of these had the specificity anti alpha2 and one anti A2m(2). The 34 IgA deficient donors detected provide a source of IgA deficient blood for transfusion to patients with anti IgA antibodies.

Documentos Relacionados

• Diaphragmatic hernia in the south-west of England.
• Molecular heterogeneity at the phenylalanine hydroxylase locus in the population of the south-west of England.
• Latex agglutination method for IgA deficiency used for large scale screening of blood donor sera.
• IgA deficiency in Israeli blood donors.
• Diocesan Licensing and Medical Practitioners in South-West England, 1660–1780