SEL-8, a nuclear protein required for LIN-12 and GLP-1 signaling in Caenorhabditis elegans

AUTOR(ES)

Doyle, Timothy G.

FONTE

The National Academy of Sciences

RESUMO

LIN-12 and GLP-1 are members of the LIN-12/Notch family of receptors that mediate cell–cell interactions during development. The sel-8 gene had been identified previously in a screen for suppressors of a mutation that constitutively activates LIN-12. Here, we report that sel-8 is essential for lin-12- and glp-1-mediated signaling, and that SEL-8 is a glutamine-rich nuclear protein. We postulate that SEL-8 serves as a transcriptional coactivator or as an assembly factor for transcription complexes that contain the LIN-12 or GLP-1 intracellular domains.

Documentos Relacionados

• HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling
• Suppressors of a Lin-12 Hypomorph Define Genes That Interact with Both Lin-12 and Glp-1 in Caenorhabditis Elegans
• Functional domains of LAG-2, a putative signaling ligand for LIN-12 and GLP-1 receptors in Caenorhabditis elegans.
• The Caenorhabditis Elegans Sel-1 Gene, a Negative Regulator of Lin-12 and Glp-1, Encodes a Predicted Extracellular Protein
• Genetic and Phenotypic Studies of Hypomorphic Lin-12 Mutants in Caenorhabditis Elegans