Selection of a Mutant of Escherichia coli Which Has High Mutation Rates
AUTOR(ES)
Helling, Robert B.
RESUMO
A mutation which causes high mutation rates in all other loci tested was induced with nitrosoguanidine and was selected through the ability of the progeny of such mutant cells to mutate to streptomycin resistance at a higher rate than the wild-type cells. This mutation (mut-2) and the Treffers' mutation (mutT1) mapped at approximately the same position to the right of leu. Specificity studies showed that the two mutations differ in rates of mutation produced.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=252407Documentos Relacionados
- Selection for High Mutation Rates in Chemostats
- Escherichia coli mutant which restricts T7 bacteriophage has an altered RNA polymerase.
- Identification of the pheS5 mutation, which causes thermosensitivity of Escherichia coli mutant NP37.
- Transport-Limited Growth Rates in a Mutant of Escherichia coli
- An Escherichia coli DNA topoisomerase I mutant has a compensatory mutation that alters two residues between functional domains of the DNA gyrase A protein.