Selective Inhibition of Deoxyribonucleic Acid Synthesis by 2-Deoxyadenosine in the Blue-Green Bacterium Agmenellum quadruplicatum
AUTOR(ES)
Ingram, L. O.
RESUMO
Concentrations of deoxyadenosine which have little effect on net ribonucleic acid (RNA) synthesis or on increase in cell mass selectively inhibit deoxyribonucleic acid (DNA) synthesis in Agmenellum quadruplicatum. Exogenously supplied deoxyadenosine, at concentrations above 10 μg/ml, stimulates DNA degradation. These results are correlated with a rapid loss in viability. Over a narrow concentration range (6–15 μg/ml), deoxyadenosine impairs the division process and induces the formation of elongated cells. Low exogenous concentrations of deoxyadenosine are readily incorporated into both DNA and RNA, with the major portion as DNA.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=251392Documentos Relacionados
- Isolation of a small-cell mutant in the blue-green bacterium Agmenellum quadruplicatum.
- Cell Division Mutations in the Blue-Green Bacterium Agmenellum quadruplicatum Strain BG1: a Comparison of the Cell Wall
- Characteristics of Nitrate Reduction in a Mutant of the Blue-Green Alga Agmenellum quadruplicatum1
- Deoxyribonucleic Acid of the Blue-Green Algae (Cyanophyta)
- Documentation of Auxotrophic Mutation in Blue-Green Bacteria: Characterization of a Tryptophan Auxotroph in Agmenellum quadruplicatum