Sequence Typing Confirms that Campylobacter jejuni Strains Associated with Guillain-Barré and Miller-Fisher Syndromes Are of Diverse Genetic Lineage, Serotype, and Flagella Type
AUTOR(ES)
Dingle, K. E.
FONTE
American Society for Microbiology
RESUMO
Guillain-Barré syndrome (GBS) and Miller-Fisher syndrome (MFS) are correlated with prior infection by Campylobacter jejuni in up to 40% of cases. Nucleotide sequence-based typing of 25 C. jejuni isolates associated with neuropathy permitted robust comparisons with equivalent data from approximately 800 C. jejuni isolates not associated with neuropathy. A total of 13 genetic lineages and 20 flaA short variable region nucleotide sequences were present among the 25 isolates. A minority of isolates (4 of 25) had the flaA short variable region nucleotide sequences that were previously proposed as a marker for GBS-associated isolates. These 4 isolates probably represented the Penner serotype 19 lineage, which has been proposed to have an association with GBS.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=88342Documentos Relacionados
- Molecular Characterization of Campylobacter jejuni from Patients with Guillain-Barré and Miller Fisher Syndromes
- Flagella as a Potential Marker for Campylobacter jejuni Strains Associated with Guillain-Barré Syndrome
- Epidemiology of Campylobacter jejuni Isolated from Patients with Guillain-Barré and Fisher Syndromes in Japan
- Miller-Fisher syndrome associated with Campylobacter jejuni bearing lipopolysaccharide molecules that mimic human ganglioside GD3.
- Structure of Campylobacter jejuni Lipopolysaccharides Determines Antiganglioside Specificity and Clinical Features of Guillain-Barré and Miller Fisher Patients