Sequences near the 5' long terminal repeat of avian leukosis viruses determine the ability to induce osteopetrosis.

AUTOR(ES)

Robinson, H L

RESUMO

Avian leukosis virus (ALV)-induced osteopetrosis is associated with the accumulation of unintegrated viral DNA in osteoblasts. Viruses constructed from the DNAs of an osteopetrosis-inducing ALV (Br21) and a non-osteopetrosis-inducing ALV (RAV-0) have been used to test for the role of viral genes in the induction of osteopetrosis. Our results map osteopetrotic potential to a 1,400-base-pair region near the 5' long terminal repeat. This region contains signals for the splicing, translation, and packaging of viral RNAs and coding sequences for the gag proteins p19 and p10 and the N terminus of p27.

Documentos Relacionados

• Influence of env and long terminal repeat sequences on the tissue tropism of avian leukosis viruses.
• Biological characterization of avian osteopetrosis.
• 5' long terminal repeats of myc-associated proviruses appear structurally intact but are functionally impaired in tumors induced by avian leukosis viruses.
• Characterization of the immunosuppression accompanying virus-induced avian osteopetrosis.
• Encapsidation sequences for spleen necrosis virus, an avian retrovirus, are between the 5' long terminal repeat and the start of the gag gene.