Serum bactericidal activity of rifampin in combination with other antimicrobial agents against Staphylococcus aureus.
AUTOR(ES)
Hackbarth, C J
RESUMO
Because rifampin-resistant strains of Staphylococcus aureus emerge during monotherapy with this drug, a search was made for potentially useful companion drugs. Bactericidal titers of spiked serum were determined, and time kill studies were performed for 10 strains of methicillin-susceptible S. aureus. We tested rifampin in combination with nafcillin, vancomycin, clindamycin, pefloxacin, ciprofloxacin, trimethoprim, teicoplanin, or erythromycin. The bactericidal activity of nafcillin, vancomycin, and teicoplanin was significantly reduced (P less than 0.05) when rifampin was added to the drug regimen. In contrast, the addition of rifampin to clindamycin or erythromycin significantly increased bactericidal activity as measured by both bactericidal titers in serum and 6-h killing rates (P less than 0.02). Bactericidal activity in serum was also increased by the addition of rifampin to trimethoprim, but rifampin-resistant strains emerged with this combination.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=180452Documentos Relacionados
- In vitro activity of rifampin in combination with oxacillin against Staphylococcus aureus.
- Bactericidal activity of antiseptics against methicillin-resistant Staphylococcus aureus.
- Bactericidal activity of oxacillin against beta-lactamase-hyperproducing Staphylococcus aureus.
- In Vitro Bactericidal Activities of Linezolid in Combination with Vancomycin, Gentamicin, Ciprofloxacin, Fusidic Acid, and Rifampin against Staphylococcus aureus
- In vitro activity of fosfomycin, alone and in combination, against methicillin-resistant Staphylococcus aureus.
