SÍNTESE DE 4-(FUR-2-IL)- E 4-(TIEN-2-IL)-PIRIMIDINAS A PARTIR DE β-ALCOXIVINIL TRIFLUORMETIL CETONAS / SYNTHESIS OF 4-(FUR-2-YL)- AND 4-(THIEN-2-YL)-PYRIMIDINES FROM β-ALKOXYVINYL TRIFLUOROMETHYL KETONES
AUTOR(ES)
Lucas Pizzuti
DATA DE PUBLICAÇÃO
2005
RESUMO
The cyclocondensation of the 1,1,1-trifluoro-4-methoxy-4-(2-heteroaryl)-3-buten-2-ones (heteroaryl = furyl and thienyl) with urea and amidines (acetamidine, benzamidine, guanidine, 1H-pyrazole-1-carboxamidine and 2-methyl-2-thiopseudourea) for synthesis of two 4-(2-heteroaryl)-6-trifluoromethylpyrimidinones and a series of ten 4-(2-heteroaryl)-6-trifluoromethylpyrimidines is reported. The reaction of the 1,1,1-trifluoro-4-methoxy-4-(2-heteroaryl)-3-buten-2-ones with urea was carried out in the presence of boron trifluoride etherate as a catalyst, at 50C for 20 hours. The reactions of the same substracts with amidines were carried out in the presence of a 1 M solution of sodium hydroxide at r.t.-50C for 1 hour. Under this conditions, only aromatic pyrimidines were obtained in 48-67%.
ASSUNTO(S)
pirimidinas sintese quimica quimica quimica
ACESSO AO ARTIGO
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