Sintese de R.M.N. de carbono-13 de haletos de 1,1 dimetil-2,6-diidro-3-ceto-piridinios-5-substituidos

AUTOR(ES)
DATA DE PUBLICAÇÃO

1995

RESUMO

The aim this work has been the synthesis and C n.m.r. studies of N-Acetony-N,N-dimethylglicine halides and 1,1-dimethyl-2,6-dihidro-3-keto-piridinium halides with substituents in the carbon-5. These new compounds are intermediates in the synthesis of pyridostigmine, a anti- cholinesterasic agent, that our group wants to synthesize. Most of compounds was synthesized through the adaptation of literature synthetic methods, with good yields. Then, to synthesize N-Acetony-N,N-dimethylglicine halides, it was used the methods developed in our laboratory; and to synthesize 5-substitued-1,1-dimethyl-2,6-dihidro-3-keto-piridinium halides it was used the same methods of synthesis of 5,5-dimethyl-2-ciclohexen-1-onas with substituents in carbon-3. Their caracterization was perfomed through melting point, Hidrogen1 and Carbon-13 n.m.r, I.R. and elemental analysis, when necessary. The interpretation of the substituent effects in the cabon-13 n.m.r. chemical-shifts were performed on the grounds of the usual concepts of Physical Organic Chemistry, by using substituents empirical effects and n.m.r. technics like HETCOR and COLOC. Empirical calculation of methylenic carbons in a- position with respect of ammonium group was made by using Hart e Ford additivity relationships.

ASSUNTO(S)

ressonancia magnetica nuclear carbono

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