Skeletal muscle engraftment potential of adult mouse skin side population cells
AUTOR(ES)
Montanaro, Federica
FONTE
National Academy of Sciences
RESUMO
Adult bone marrow and skeletal muscle have been shown to contain a subpopulation of cells, called side population (SP) cells, that can be isolated with the fluorescence-activated cell sorter. We used a similar method to identify SP cells in the skin of adult mice. These cells express surface markers similar to SP cells isolated from skeletal muscle, but differ from bone marrow SP cells and do not express hematopoietic markers. When transplanted into nonirradiated mdx mice, nuclei from donor skin SP cells are found within myofibers that express dystrophin. Thus, adult skin SP cells can engraft in dystrophic skeletal muscle even in the absence of total body irradiation.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=170919Documentos Relacionados
- Mouse Pop1 Is Required for Muscle Regeneration in Adult Skeletal Muscle
- Transplanted hematopoietic stem cells demonstrate impaired sarcoglycan expression after engraftment into cardiac and skeletal muscle
- Genetic correction of dystrophin deficiency and skeletal muscle remodeling in adult MDX mouse via transplantation of retroviral producer cells.
- Hematopoietic potential of stem cells isolated from murine skeletal muscle
- Interstitial space of mouse skeletal muscle