Solid-phase synthesis of an RNA nucleopeptide fragment from the nucleoprotein of poliovirus.

AUTOR(ES)

Dreef-Tromp, C M

RESUMO

The naturally occurring RNA-nucleopeptide H-Ala-Tyr[5'-pUUAAAAC-3']-NH2 is prepared via a solid-phase phosphite triester approach using N-SiOMB/O-TBDMS-protected nucleosides. Preliminary 1H-NMR studies show that the peptidyl unit has a remarkable effect on the conformational behaviour of the RNA moiety in the nucleopeptide.

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