Source of Neuraminidase in Human Whole Saliva
AUTOR(ES)
Fukui, Yoshio
RESUMO
Whole saliva specimens from eight healthy human adults were examined for neuraminidase. The presence of two types of neuraminidase in four samples out of eight was demonstrated by means of polyacrylamide gel electrophoresis and sucrose density gradient centrifugation. One type is soluble and the other an insoluble, perhaps particle-bound, enzyme. The pH optima were 5.8 for the former and 5.0 to 5.3 for the latter. However, the soluble enzyme could not be detected in the other four saliva specimens which showed low activity. A comparative study of the salivary and other neuraminidases was carried out. It was found that both salivary neuraminidases were closely similar to the enzymes in submandibular-sublingual secretions and in human liver, but not to the oral streptococcal enzymes. The results suggest that the salivary neuraminidases might originate from cells such as epithelial cells or polymorphonuclear leukocytes, or both, in the oral cavity.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=422852Documentos Relacionados
- Antimicrobial factors in whole saliva of human infants.
- Chemical analysis of whole saliva in Sjögren's syndrome.
- Promotion of Streptococcus mutans glucose transport by human whole saliva and parotid fluid.
- Adsorption of Lysozyme from Human Whole Saliva by Streptococcus sanguis 903 and Other Oral Microorganisms
- Inhibitory activity in saliva of cell-to-cell transmission of human T-cell lymphotropic virus type 1 in vitro: evaluation of saliva as an alternative source of transmission.
